Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection.
Identifieur interne : 000162 ( Main/Exploration ); précédent : 000161; suivant : 000163Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection.
Auteurs : Mengling Tang [République populaire de Chine] ; Zhiqiang Hu [République populaire de Chine] ; Chenglong Rao [République populaire de Chine] ; Jiangao Chen [République populaire de Chine] ; Siqi Yuan [République populaire de Chine] ; Jiangang Zhang [République populaire de Chine] ; Chan Mao [République populaire de Chine] ; Jingmin Yan [République populaire de Chine] ; Yupei Xia [République populaire de Chine] ; Meijuan Zhang [République populaire de Chine] ; Juanjuan Yue [République populaire de Chine] ; Yang Xiang [République populaire de Chine] ; Jianping Xie [République populaire de Chine] ; Xuhu Mao [République populaire de Chine] ; Qian Li [République populaire de Chine]Source :
- Autophagy [ 1554-8635 ] ; 2020.
Abstract
BURKHOLDERIA PSEUDOMALLEI
which causes melioidosis with high mortality in humans, has become a global public health concern. Recently, infection-driven lipid droplet accumulation has been related to the progression of host-pathogen interactions, and its contribution to the pathogenesis of infectious disease has been investigated. Here, we demonstrated that
ABBREVIATIONS
3-MA: 3-methyladenine; ACTB: actin beta; ATG7: autophagy related 7;
DOI: 10.1080/15548627.2020.1801270
PubMed: 32777979
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><i>Burkholderia pseudomallei</i> interferes with host lipid metabolism via <i>NR1D2</i>-mediated <i>PNPLA2/ATGL</i> suppression to block autophagy-dependent inhibition of infection.</title><author><name sortKey="Tang, Mengling" sort="Tang, Mengling" uniqKey="Tang M" first="Mengling" last="Tang">Mengling Tang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Zhiqiang" sort="Hu, Zhiqiang" uniqKey="Hu Z" first="Zhiqiang" last="Hu">Zhiqiang Hu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Rao, Chenglong" sort="Rao, Chenglong" uniqKey="Rao C" first="Chenglong" last="Rao">Chenglong Rao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Jiangao" sort="Chen, Jiangao" uniqKey="Chen J" first="Jiangao" last="Chen">Jiangao Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of General Medicine, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of General Medicine, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Siqi" sort="Yuan, Siqi" uniqKey="Yuan S" first="Siqi" last="Yuan">Siqi Yuan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jiangang" sort="Zhang, Jiangang" uniqKey="Zhang J" first="Jiangang" last="Zhang">Jiangang Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Medicine Research Center, Xinqiao Hospital, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Clinical Medicine Research Center, Xinqiao Hospital, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Mao, Chan" sort="Mao, Chan" uniqKey="Mao C" first="Chan" last="Mao">Chan Mao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Jingmin" sort="Yan, Jingmin" uniqKey="Yan J" first="Jingmin" last="Yan">Jingmin Yan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Xia, Yupei" sort="Xia, Yupei" uniqKey="Xia Y" first="Yupei" last="Xia">Yupei Xia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Meijuan" sort="Zhang, Meijuan" uniqKey="Zhang M" first="Meijuan" last="Zhang">Meijuan Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Yue, Juanjuan" sort="Yue, Juanjuan" uniqKey="Yue J" first="Juanjuan" last="Yue">Juanjuan Yue</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Xiang, Yang" sort="Xiang, Yang" uniqKey="Xiang Y" first="Yang" last="Xiang">Yang Xiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Xie, Jianping" sort="Xie, Jianping" uniqKey="Xie J" first="Jianping" last="Xie">Jianping Xie</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Mao, Xuhu" sort="Mao, Xuhu" uniqKey="Mao X" first="Xuhu" last="Mao">Xuhu Mao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Li, Qian" sort="Li, Qian" uniqKey="Li Q" first="Qian" last="Li">Qian Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32777979</idno><idno type="pmid">32777979</idno><idno type="doi">10.1080/15548627.2020.1801270</idno><idno type="wicri:Area/Main/Corpus">000032</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000032</idno><idno type="wicri:Area/Main/Curation">000032</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000032</idno><idno type="wicri:Area/Main/Exploration">000032</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en"><i>Burkholderia pseudomallei</i> interferes with host lipid metabolism via <i>NR1D2</i>-mediated <i>PNPLA2/ATGL</i> suppression to block autophagy-dependent inhibition of infection.</title><author><name sortKey="Tang, Mengling" sort="Tang, Mengling" uniqKey="Tang M" first="Mengling" last="Tang">Mengling Tang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Zhiqiang" sort="Hu, Zhiqiang" uniqKey="Hu Z" first="Zhiqiang" last="Hu">Zhiqiang Hu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Rao, Chenglong" sort="Rao, Chenglong" uniqKey="Rao C" first="Chenglong" last="Rao">Chenglong Rao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Jiangao" sort="Chen, Jiangao" uniqKey="Chen J" first="Jiangao" last="Chen">Jiangao Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of General Medicine, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of General Medicine, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Siqi" sort="Yuan, Siqi" uniqKey="Yuan S" first="Siqi" last="Yuan">Siqi Yuan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jiangang" sort="Zhang, Jiangang" uniqKey="Zhang J" first="Jiangang" last="Zhang">Jiangang Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Medicine Research Center, Xinqiao Hospital, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Clinical Medicine Research Center, Xinqiao Hospital, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Mao, Chan" sort="Mao, Chan" uniqKey="Mao C" first="Chan" last="Mao">Chan Mao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Jingmin" sort="Yan, Jingmin" uniqKey="Yan J" first="Jingmin" last="Yan">Jingmin Yan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Xia, Yupei" sort="Xia, Yupei" uniqKey="Xia Y" first="Yupei" last="Xia">Yupei Xia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Meijuan" sort="Zhang, Meijuan" uniqKey="Zhang M" first="Meijuan" last="Zhang">Meijuan Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Yue, Juanjuan" sort="Yue, Juanjuan" uniqKey="Yue J" first="Juanjuan" last="Yue">Juanjuan Yue</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Xiang, Yang" sort="Xiang, Yang" uniqKey="Xiang Y" first="Yang" last="Xiang">Yang Xiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Xie, Jianping" sort="Xie, Jianping" uniqKey="Xie J" first="Jianping" last="Xie">Jianping Xie</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Mao, Xuhu" sort="Mao, Xuhu" uniqKey="Mao X" first="Xuhu" last="Mao">Xuhu Mao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Li, Qian" sort="Li, Qian" uniqKey="Li Q" first="Qian" last="Li">Qian Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author></analytic><series><title level="j">Autophagy</title><idno type="eISSN">1554-8635</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BURKHOLDERIA PSEUDOMALLEI</b></p><p>which causes melioidosis with high mortality in humans, has become a global public health concern. Recently, infection-driven lipid droplet accumulation has been related to the progression of host-pathogen interactions, and its contribution to the pathogenesis of infectious disease has been investigated. Here, we demonstrated that </p></div><div type="abstract" xml:lang="en"><p><b>ABBREVIATIONS</b></p><p>3-MA: 3-methyladenine; ACTB: actin beta; ATG7: autophagy related 7; </p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32777979</PMID><DateRevised><Year>2020</Year><Month>08</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1554-8635</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Aug</Month><Day>11</Day></PubDate></JournalIssue><Title>Autophagy</Title><ISOAbbreviation>Autophagy</ISOAbbreviation></Journal><ArticleTitle><i>Burkholderia pseudomallei</i> interferes with host lipid metabolism via <i>NR1D2</i>-mediated <i>PNPLA2/ATGL</i> suppression to block autophagy-dependent inhibition of infection.</ArticleTitle><Pagination><MedlinePgn>1-16</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/15548627.2020.1801270</ELocationID><Abstract><AbstractText Label="BURKHOLDERIA PSEUDOMALLEI" NlmCategory="UNASSIGNED">which causes melioidosis with high mortality in humans, has become a global public health concern. Recently, infection-driven lipid droplet accumulation has been related to the progression of host-pathogen interactions, and its contribution to the pathogenesis of infectious disease has been investigated. Here, we demonstrated that <i>B. pseudomallei</i> infection actively induced a time-dependent increase in the number and size of lipid droplets in human lung epithelial cells and macrophages. We also found that lipid droplet accumulation following <i>B. pseudomallei</i> infection was associated with downregulation of <i>PNPLA2/ATGL</i> (patatin like phospholipase domain containing 2) and lipophagy inhibition. Functionally, lipid droplet accumulation, facilitated via <i>PNPLA2</i> downregulation, inhibited macroautophagic/autophagic flux and, thus, hindered autophagy-dependent inhibition of <i>B. pseudomallei</i> infection in lung epithelial cells. Mechanistically, we further revealed that nuclear receptor <i>NR1D2</i> might be involved in the suppression of <i>PNPLA2</i> after cell exposure to <i>B. pseudomallei</i>. Taken together, our findings unraveled an evolutionary strategy, by which <i>B. pseudomallei</i> interferes with the host lipid metabolism, to block autophagy-dependent suppression of infection. This study proposes potential targets for clinical therapy of melioidosis.</AbstractText><AbstractText Label="ABBREVIATIONS" NlmCategory="BACKGROUND">3-MA: 3-methyladenine; ACTB: actin beta; ATG7: autophagy related 7; <i>B. pseudomallei: Burkholderia pseudomallei</i>; CFU: colony-forming unit; DG: diglyceride; FASN: fatty acid synthase; GFP: green fluorescent protein; LAMP1: lysosomal associated membrane protein 1; LC-MS/MS: liquid chromatography-tandem mass spectrometry; LD: lipid droplet; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MG: monoglyceride; MOI: multiplicity of infection; mRFP: monomeric red fluorescent protein; NR1D2: nuclear receptor subfamily 1 group D member 2; p.i., post-infection; PLIN2/ADRP: perilipin 2; PNPLA2/ATGL: patatin like phospholipase domain containing 2; Rapa: rapamycin; SQSTM1/p62: sequestosome 1; shRNA: short hairpin RNA; TEM: transmission electron microscopy; TG: triglyceride.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Mengling</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University , Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Zhiqiang</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rao</LastName><ForeName>Chenglong</ForeName><Initials>C</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-6110-2332</Identifier><AffiliationInfo><Affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Jiangao</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of General Medicine, Southwest Hospital, Army Medical University (Third Military Medical University) , Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yuan</LastName><ForeName>Siqi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University , Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jiangang</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Clinical Medicine Research Center, Xinqiao Hospital, Army Medical University (Third Military Medical University) , Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mao</LastName><ForeName>Chan</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Jingmin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xia</LastName><ForeName>Yupei</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Meijuan</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yue</LastName><ForeName>Juanjuan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiang</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Jianping</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University , Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mao</LastName><ForeName>Xuhu</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Qian</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University) , Chongqing, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Autophagy</MedlineTA><NlmUniqueID>101265188</NlmUniqueID><ISSNLinking>1554-8627</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N"> Burkholderia pseudomallei </Keyword><Keyword MajorTopicYN="N">Autophagy</Keyword><Keyword MajorTopicYN="N">NR1D2</Keyword><Keyword MajorTopicYN="N">PNPLA2/ATGL</Keyword><Keyword MajorTopicYN="N">lipid droplet</Keyword><Keyword MajorTopicYN="N">lipid metabolism</Keyword><Keyword MajorTopicYN="N">lipophagy</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32777979</ArticleId><ArticleId IdType="doi">10.1080/15548627.2020.1801270</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Tang, Mengling" sort="Tang, Mengling" uniqKey="Tang M" first="Mengling" last="Tang">Mengling Tang</name></noRegion><name sortKey="Chen, Jiangao" sort="Chen, Jiangao" uniqKey="Chen J" first="Jiangao" last="Chen">Jiangao Chen</name><name sortKey="Chen, Jiangao" sort="Chen, Jiangao" uniqKey="Chen J" first="Jiangao" last="Chen">Jiangao Chen</name><name sortKey="Hu, Zhiqiang" sort="Hu, Zhiqiang" uniqKey="Hu Z" first="Zhiqiang" last="Hu">Zhiqiang Hu</name><name sortKey="Li, Qian" sort="Li, Qian" uniqKey="Li Q" first="Qian" last="Li">Qian Li</name><name sortKey="Mao, Chan" sort="Mao, Chan" uniqKey="Mao C" first="Chan" last="Mao">Chan Mao</name><name sortKey="Mao, Xuhu" sort="Mao, Xuhu" uniqKey="Mao X" first="Xuhu" last="Mao">Xuhu Mao</name><name sortKey="Rao, Chenglong" sort="Rao, Chenglong" uniqKey="Rao C" first="Chenglong" last="Rao">Chenglong Rao</name><name sortKey="Tang, Mengling" sort="Tang, Mengling" uniqKey="Tang M" first="Mengling" last="Tang">Mengling Tang</name><name sortKey="Xia, Yupei" sort="Xia, Yupei" uniqKey="Xia Y" first="Yupei" last="Xia">Yupei Xia</name><name sortKey="Xiang, Yang" sort="Xiang, Yang" uniqKey="Xiang Y" first="Yang" last="Xiang">Yang Xiang</name><name sortKey="Xie, Jianping" sort="Xie, Jianping" uniqKey="Xie J" first="Jianping" last="Xie">Jianping Xie</name><name sortKey="Yan, Jingmin" sort="Yan, Jingmin" uniqKey="Yan J" first="Jingmin" last="Yan">Jingmin Yan</name><name sortKey="Yuan, Siqi" sort="Yuan, Siqi" uniqKey="Yuan S" first="Siqi" last="Yuan">Siqi Yuan</name><name sortKey="Yuan, Siqi" sort="Yuan, Siqi" uniqKey="Yuan S" first="Siqi" last="Yuan">Siqi Yuan</name><name sortKey="Yue, Juanjuan" sort="Yue, Juanjuan" uniqKey="Yue J" first="Juanjuan" last="Yue">Juanjuan Yue</name><name sortKey="Zhang, Jiangang" sort="Zhang, Jiangang" uniqKey="Zhang J" first="Jiangang" last="Zhang">Jiangang Zhang</name><name sortKey="Zhang, Meijuan" sort="Zhang, Meijuan" uniqKey="Zhang M" first="Meijuan" last="Zhang">Meijuan Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000162 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000162 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32777979
|texte= Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32777979" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |